Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats
نویسندگان
چکیده
منابع مشابه
Prolonged protein deprivation differentially affects calretinin- and parvalbumin-containing interneurons in the hippocampal dentate gyrus of adult rats.
Protein deprivation is a detrimental nutritional state that induces several deleterious changes in the rat hippocampal formation. In this study, we compared the effects of protein deprivation in the number of parvalbumin (PV)-immunoreactive and calretinin (CR)-immunoreactive interneurons of the dentate gyrus, which are involved in the control of calcium homeostasis and fine tuning of the hippoc...
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The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...
متن کاملDentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats.
New granule cells are born throughout life in the dentate gyrus of the hippocampal formation. Given the fundamental role of the hippocampus in processes underlying certain forms of learning and memory, it has been speculated that newborn granule cells contribute to cognition. However, previous strategies aiming to causally link newborn neurons with hippocampal function used ablation strategies ...
متن کاملOxytocin improves autistic-like behaviors induced by maternal deprivation in female rats
Background and Objective: Maternal deprivation as an early life negative experience can lead to enduring disorders such as autism-like behaviors by affecting brain development. Oxytocinergic system alters in the process of maternal deprivation, on the other hand the positive effect of oxytocin on the improvement of social behavior and stereotyped behavior in autism disorder has been shown. In t...
متن کاملChronic Social Stress Affects Synaptic Maturation of Newly Generated Neurons in the Adult Mouse Dentate Gyrus.
BACKGROUND Chronic stress has been found to suppress adult neurogenesis, but it remains unclear whether it may affect the maturation process of adult-born neurons. Here, we examined the influence of chronic social defeat stress on the morphological and electrophysiological properties of adult-born dentate granule cells at different developmental stages. METHODS Adult C57BL/6 mice were subject...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2010
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-010-1922-8